| L | Max Holloway | UFC 318 - Holloway vs. Poirier 3 | DECISION UNANIMOUS | 5 (5:00) | Jul 19, 2025 |
| L | Islam Makhachev | UFC 302: Makhachev vs. Poirier | SUBMISSION | 5 (2:42) | Jun 1, 2024 |
| W | Benoit St. Denis | UFC 299: O'Malley vs. Vera 2 | KO TKO | 2 (2:32) | Mar 9, 2024 |
| W | Benoit Saint Denis | UFC 299: O'Malley vs. Vera 2 | KO TKO | 2 (2:32) | Mar 9, 2024 |
| L | Justin Gaethje | UFC 291 - Poirier vs. Gaethje 2 | KO TKO | 2 (1:00) | Jul 29, 2023 |
| W | Michael Chandler | UFC 281 - Adesanya vs. Pereira | SUBMISSION | 3 (2:00) | Nov 12, 2022 |
| L | Charles Oliveira | UFC 269 - Oliveira vs. Poirier | SUBMISSION | 3 (1:02) | Dec 11, 2021 |
| W | Conor McGregor | UFC 264 - Poirier vs. McGregor 3 | KO TKO | 1 (5:00) | Jul 10, 2021 |
| W | Conor McGregor | UFC 257 - Poirier vs. McGregor 2 | KO TKO | 2 (2:32) | Jan 23, 2021 |
| W | Dan Hooker | UFC on ESPN 12 - Poirier vs. Hooker | DECISION UNANIMOUS | 5 (5:00) | Jun 27, 2020 |
| L | Khabib Nurmagomedov | UFC 242 - Khabib vs. Poirier | SUBMISSION | 3 (2:06) | Sep 7, 2019 |
| W | Max Holloway | UFC 236: Holloway vs. Poirier 2 | DECISION UNANIMOUS | 5 (5:00) | Apr 13, 2019 |
| — | Nate Diaz | UFC 230 - Cormier vs. Lewis | — | — | Nov 3, 2018 |
| W | Eddie Alvarez | UFC on Fox 30 - Alvarez vs. Poirier 2 | KO TKO | 2 (4:05) | Jul 28, 2018 |
| W | Justin Gaethje | UFC on Fox 29 - Poirier vs. Gaethje | KO TKO | 4 (0:33) | Apr 14, 2018 |
| W | Anthony Pettis | UFC Fight Night 120 - Poirier vs. Pettis | SUBMISSION | 3 (2:08) | Nov 11, 2017 |
| NC | Eddie Alvarez | UFC 211 - Miocic vs. Dos Santos 2 | NC | 2 (4:12) | May 13, 2017 |
| W | Jim Miller | UFC 208 - Holm vs. De Randamie | DECISION MAJORITY | 3 (5:00) | Feb 11, 2017 |
| L | Michael Johnson | UFC Fight Night 94 - Poirier vs. Johnson | KO TKO | 1 (1:35) | Sep 17, 2016 |
| W | Bobby Green | UFC 199 - Rockhold vs. Bisping 2 | KO TKO | 1 (2:53) | Jun 4, 2016 |
| W | Joseph Duffy | UFC 195 - Lawler vs. Condit | DECISION UNANIMOUS | 3 (5:00) | Jan 2, 2016 |
| W | Joe Duffy | UFC 195 - Lawler vs. Condit | DECISION UNANIMOUS | 3 (5:00) | Jan 2, 2016 |
| W | Yancy Medeiros | UFC Fight Night 68 - Boetsch vs. Henderson | KO TKO | 1 (2:38) | Jun 6, 2015 |
| W | Diego Ferreira | UFC Fight Night 63 - Mendes vs. Lamas | KO TKO | 1 (3:45) | Apr 4, 2015 |
| L | Conor McGregor | UFC 178 - Johnson vs. Cariaso | KO TKO | 1 (1:46) | Sep 27, 2014 |
| W | Akira Corassani | UFC - The Ultimate Fighter Nations Finale | KO TKO | 2 (0:42) | Apr 16, 2014 |
| W | Diego Brandao | UFC 168 - Weidman vs. Silva 2 | KO TKO | 1 (4:54) | Dec 28, 2013 |
| W | Erik Koch | UFC 164 - Henderson vs. Pettis 2 | DECISION UNANIMOUS | 3 (5:00) | Aug 31, 2013 |
| L | Cub Swanson | UFC on Fuel TV 7 - Barao vs. McDonald | DECISION UNANIMOUS | 3 (5:00) | Feb 16, 2013 |
| W | Jonathan Brookins | UFC - The Ultimate Fighter 16 Finale | SUBMISSION | 1 (4:15) | Dec 15, 2012 |
| L | Chan Sung Jung | UFC on Fuel TV 3 - Korean Zombie vs. Poirier | SUBMISSION | 4 (1:07) | May 15, 2012 |
| W | Max Holloway | UFC 143 - Diaz vs. Condit | SUBMISSION | 1 (3:23) | Feb 4, 2012 |
| W | Pablo Garza | UFC on Fox 1 - Velasquez vs. Dos Santos | SUBMISSION | 2 (1:32) | Nov 12, 2011 |
| W | Jason Young | UFC 131 - Dos Santos vs. Carwin | DECISION UNANIMOUS | 3 (5:00) | Jun 11, 2011 |
| W | Josh Grispi | UFC 125 - Resolution | DECISION UNANIMOUS | 3 (5:00) | Jan 1, 2011 |
| W | Zachary Micklewright | WEC 52 - Faber vs. Mizugaki | KO TKO | 1 (0:53) | Nov 11, 2010 |
| L | Danny Castillo | WEC 50 - Cruz vs. Benavidez 2 | DECISION UNANIMOUS | 3 (5:00) | Aug 18, 2010 |
| W | Derek Gauthier | Ringside MMA 7 - No Escape | KO TKO | 1 (0:57) | Jun 18, 2010 |
| W | Derrick Krantz | USA MMA - Night of Champions 2 | SUBMISSION | 2 (3:35) | Mar 6, 2010 |
| W | Ronnie Lis | USA MMA - Border War 2 | SUBMISSION | 1 (0:51) | Nov 13, 2009 |
| W | Daniel Watts | BFC - Bang Fighting Championships | KO TKO | 1 (1:26) | Oct 31, 2009 |
| W | Joe Torrez | USA MMA 8 - Natural Disaster 3 | KO TKO | 1 (2:37) | Aug 1, 2009 |
| W | Nate Jolly | CFC - Cajun Fighting Championships | SUBMISSION | 2 (3:54) | Jun 26, 2009 |
| W | Aaron Suarez | USA MMA 7 - River City Rampage | KO TKO | 1 (1:19) | May 16, 2009 |
| W | Gilbert Jimenez | No Love Entertainment - Full Throttle | DECISION UNANIMOUS | 3 (4:00) | Jan 24, 2009 |
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